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Traditional Chinese Medicine (32)
  1. Chan GK, Guo MS, Dai DK, Lai QW, Fung KW, Zheng BZ, Wu KQ, Man BK, Dong TT, Tsim KW* (2020). An optimized extract, named Self-Growth Colony, from platelet-rich plasma shows robust skin rejuvenation and anti-ageing properties: a novel technology in development of cosmetics. Skin Pharmacology and Physiology, 34(2):74 - 85.
  2. Xia YT, Chan GK, Wang HY, Dong TT, Duan R, Hu WH, Qin QW, Wang WX, Tsim KW*. (2020). The anti-bacterial effects of aerial parts of Scutellaria baicalnsis: Potential application as an additive in aquaculture feedings. Aquaculture 735418.
  3. Hu WH, Chan GK, Duan R, Wang HY, Kong XP, Dong TT, Tsim KW*. (2019) Synergy of ginkgetin and resveratrol in suppressing VEGF-induced angiogenesis: A therapy in treating colorectal cancer. Cancers, 11(12): 1828.
  4. Hu WH, Duan R, Xia YT, Xiong QP, Wang HY, Chan GK, Liu SY, Dong TT, Qin QW, Tsim KW*. (2019). Binding of resveratrol to vascular endothelial growth factor suppresses angiogenesis by inhibiting the receptor signaling. Journal of Agricultural Food Chemistry 67: 1127 – 1137.
  5. Hu WH, Wang HY, Kong XP, Poon KK, Xu L, Duan R, Wang Y, Chan GK, Dong TT, Tsim WK*. (2019). Polydatin suppresses the vascular endothelial growth factor (VEGF)-induced angiogenesis through binding with VEGF and inhibiting its receptor signalling. FASEB J. 33: 1 – 13.
  6. Wu QY, Wong ZC, Wang C, Fung AH, Wong EO, Chan GK, Dong TT, Chen Y, Tsim KW*. (2018). Isoorientin derived from Gentiana veitchiorum Hemsl. flowers inhibits melanogenesis by down-regulating MITF-induced tyrosinase expression. Phytomedicine. 57: 129 – 136.
  7. Wong CF, Chan GK, Dong TT, Tsim KW*. (2018). Origin of red color in edible bird's nests directed by the binding of Fe ions to acidic mammalian chitinase-like protein. Journal of Agricultural Food Chemistry 66 : 5644 – 5653.
  8. Wong CF, Chan GK, Wu KQ, Poon KK, Dong TT, Tsim KW*. (2018). Completed digestion of Edible Bird’s Nest releases free N-acetyl-neuraminic acid and small peptide: an efficiency method to improve functional properties. Food and Function.
  9. Hu WH, Chan GK, Lou JS, Wu QY, Wang HY, Duan R, Cheng MY, Dong TT, Tsim KW*. (2018). The Extract of Polygoni Cuspidati Rhizoma et Radix Suppresses the Vascular Endothelial Growth Factor-induced Angiogenesis. Phytomedicine. 42: 135 – 143.
  10. Chan GK*, Wu KQ, Fung AH, Poon KK, Wang CY, Gridneva E, Huang RR, Fung SY, Xia YT, Hu WW, Wong ZC and Tsim KW. (2018). Searching for Active Ingredients in Edible Bird’s Nest. J Complement Med Alt Healthcare 6(2): 555683. DOI: 10.19080/JCMAH.2018.06.555683.
  11. Chan GK*, Wu RT, Chen VP, Zhu KY, Du YQ. (2018). Quality control on herbal medicine and its application. Evid-Based Compl Alt. 2018.
  12. Chan GK, Hu WW, Zheng ZX, Huang M, Lin YX, Wang CY, Gong AG, Tsim KW, Dong TT*. (2018). Quercetin Potentiates the NGF-induced Effects in Cultured PC 2 12 Cells: Identification by HerboChips Showing a Binding with NGF. Evid-Based Compl Alt. 2018.
  13. Wong CF, Chan GK, Wu L, Lam HN, Yao P, Dong TT, Tsim KW*. (2018). A comprehensive proteomics study on edible bird’s nest using new monoclonal antibody and application in quality control. Journal of Food Composition and Analysis 66: 145 – 151.
  14. Wong CF, Chan GK, Zhang ML, Yao P, Lin HQ, Dong TT, Li G, Lai XP, Tsim KW*. (2017). Characterization of edible bird's nest by peptide fingerprinting with principal component analysis. Food Quality and Safety 1: 83 - 92.
  15. Lou JS, Bi WC, Chan GK, Jin Y, Wong CW, Zhou ZY, Wang HY, Yao P, Dong TT, Tsim KW*. (2017). Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget. 8(54): 93131 - 93148.
  16. Chan GK, Wu KQ, Wong ZC, Fung AH, Lin XY, Lou LJ, Dong TT, Tsim KW*. (2016). A high throughput screening platform for skin tuning properties from natural products: identification of skin tanning compounds. Journal of Cosmetics, Dermatological Sciences and Applications 6: 199-209.
  17. Lam KY, Ku CF, Wang HY, Chan GK, Yao P, Lin HQ, Dong TT, Zhang HJ and Tsim KW*. (2016). Authentication of Acori Tatarinowii Rhizoma (Shi Chang Pu) and its adulterants by morphological distinction, chemical composition and ITS sequencing. Chinese Medicine 11(41), DOI: 10.1186/s13020-016-0113-x.
  18. Lou JS, Yan L, Bi CW, Chan GK, Wu QY, Liu YL, Huang Y, Yao P,. Du CY, Dong TT, Tsim W*. (2016). Yu Ping Feng San reverses cisplatin-induced multi-drug resistance in lung cancer cells via regulating drug transporters and p62/TRAF6 signalling. Scientific Reports 8, 1 - 14
  19. Xiong AZ, Yan AL, Bi CW, Lam KY, Chan GK, Lau KK, Dong TT, Lin HQ, Yang L, Wang ZT, Tsim KW*. (2016). Clivorine, an otonecine pyrrolizidine alkaloid from Ligularia species, impairs neuronal. Phytomedicine, 23 (9), 931-938.
  20. Lee PS, Zhang LM, Yan AL, Lam KY, Dong TT, Lin HQ, Chan GK, Tsim KW*. (2016). Indication of nerve growth factor binding components from herbal extracts by HerboChip: a platform for drug screening on a chip. Chinese Medicine 11 (34).
  21. Lam KY, Chan GK, Xin GZ, Xu H, Ku CF, Chen JP, Yao P, Lin HQ, Dong TT, Tsim KW*. (2015). Authentication of Cordyceps sinensis by DNA analyses: comparison of ITS sequence analysis and RAPD-derived molecular markers. Molecules 20: 22454-22462
  22. Chan GK, Wong ZC, Lam KY, Cheng LK, Zhang LM, Lin H, Dong TT, Tsim KW*. (2015). Edible bird’s nest, an Asian health food supplement, possesses skin lightening activities: identification of N-acetylneuraminic acid as active ingredient. Journal of Cosmetics, Dermatological Sciences and Applications 5: 262-274.
  23. Xin GZ, Lam YC, Maiwulanjiang M, Chan GK, Zhu KY, Tang WL, Dong TT, Shi ZQ, Li P, Tsim KW*. (2014). Authentication of Bulbus Fritillariae Cirrhosae by RAPD-Derived DNA Markers. Molecules 19: 3450-3459.
  24. Xu H, Dong TT, Zhao KJ, Chan KL; Lin YJ, Tsim KW*. (2014). Study on identification of Cordyceps - A Chinese traditional medicine. China Pharmacy Journal 49:84-87.
  25. Chen JP, Lam CT, Kong AY, Zhang WL, Zhan JY, Bi CW, Chan GK, Lam KY, Yao P, Dong TT, Tsim KW*. (2014). The Extract of Ziziphus jujuba Fruit (Jujube) Induces Expression of Erythropoietin Via Hypoxia-Inducible Factor-1α in Cultured Hep3B Cells. Planta Med 80 (17): 1622-1627.
  26. Chan GK, Zhu KY, Chou DJ, Guo AJ, Lau DT, Dong TT and Tsim KW*. (2013). Surveillance of nitrite level in cubilose: Evaluation of removal method and proposed origin of contamination. Food Control 34:637-644.
  27. Chan GK, Zheng KY, Zhu KY, Dong TT and Tsim KW*. (2013). Determination of free N- acetylneuraminic acid in edible bird nest: A development of chemical marker for quality control. Journal of Ethnobiology and Traditional Medicine 120: 620-628
  28. Zheng KY, Guo AJ, Bi CW, Zhu KY, Chan GK, Fu Q, Xu SL, Zhan JY, Lau DT, Dong TT, Choi RC and Tsim KW*. (2011). The extract of Rhodiolae Crenulatae Radix et Rhizoma induces the accumulation of HIF-1α via blocking the degradation pathway in cultured kidney fibroblasts. Planta Med. 77(9):894-899.
  29. Lin HQ, Choi R, Chan KL, Ip D, Tsim KWK, Wan DC (2010)*. Differential gene expression profiling on the muscle of acetylcholinesterase knockout mice: a preliminary analysis. Chem Biol Interact 187:120-123.
  30. Zheng KY, Choi RC, Xie HQ, Cheung AW, Guo AJ, Leung KW, Chen VP, Bi CW, Zhu KY, Chan GK, Fu Q, Lau DT, Dong TT, Zhao KJ and Tsim KW. (2010)*. The expression of erythropoietin triggered by Danggui Buxue Tang, a Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells. J Ethnopharmacol. 132(1):259-267.
  31. Zhang Z, Chan GK, Li J, Fong WF and Cheung HY. (2008)*. Molecular Interaction between Andrographolide and Glutathione Follows Second Order Kinetics. Chem Pharm Bull (Tokyo) 56(9):1229-1233.
  32. Li J, Cheung HY, Zhang Z, Chan GK and Fong WF. (2007)*. Andrographolide induces cell cycle arrest at G2/M phase and cell death in HepG2 cells via alteration of reactive oxygen species. Eur J Pharmacol 568(1-3):31 – 44.
Neurosciences (5)
  1. Chen VP, Luk WK, Chan WK, Leung KW, Guo AJ, Chan GK, Xu SL, Choi RC and Tsim KW. (2011)*. Molecular assembly and biosynthesis of acetylcholinesterase in brain and muscle: the roles of t-peptide, FHB domain, and N-linked glycosylation. Front Mol Neurosci. 4:36 doi: 10.3389/fnmol.2011.00036
  2. Chen VP, Choi RC, Chan WK, Leung KW, Guo AJ, Chan GK, Luk WK and Tsim KW*. (2011). The assembly of proline-rich membrane anchor (PRiMA)-linked acetylcholinesterase enzyme: glycosylation is required for enzymatic activity but not for oligomerization. J Biol Chem. 286(38):32948 – 32961.
  3. Siow NL, Choi RC, Xie HQ, Kong LW, Chu GK, Chan GK, Simon J, Barnard EA and Tsim KW. (2010)*. ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Mol Pharmacol. 78(6):1059-71
  4. Chen VP, Xie HQ, Chan WK, Leung KW, Chan GK, Choi RC, Bon S, Massoulié J and Tsim KW. (2010)*. The PRiMA-linked cholinesterase tetramers are assembled from homodimers: hybrid molecules composed of acetylcholinesterase and butyrylcholinesterase dimers are up- regulated during development of chicken brain. J Biol Chem. 285 (35):27265 – 27278..
  5. Xie HQ, Leung KW, Chen VP, Chan GK, Xu SL, Guo AJ, Zhu KY, Zheng KY, Bi CW, Zhan JY, Chan WK, Choi RC and Tsim KW*. (2010). PRiMA directs a restricted localization of tetrameric AChE at synapses. Chem Biol Interact. 187(1-3):78-83.
Environmental Sciences (1)
  1. Cheung HY*, Chan GK, Cheung MS, Sun SQ and Fong WF (2006). Morphological and chemical changes in the attached cells of Pseudomonas aeruginosa as primary biofilms develop on aluminum and CaF2 plates. J Appl Microbiol 102(3):701 – 710.
  1. Tsim KW, Dong TT, Chan GK, Wong ZC and Wu KQ (2020). Preparation method and application of aqueous extract of Bracteantha bracteata flowers. China Patent ZL 201710338669.5, filed on 12th May, 2017 and issued on 25th December, 2020.
  2. Tsim KW, Tsoi WS, Tsoi WK, Chan GK, Dong TT (2020). An extraction method and application of growth factors from platelet. China Patent CN 202010741658.3, filed on 29th July, 2020.
  3. Cheung FY, Wen C, Tsim KW, Dong TT, Wang B and Chan GK (2020). Extract of Cordyceps sinensis, the preparation method and the use thereof. China Patent CN 201410510788.0, filed on 28th September, 2014 and issued on 3rd July, 2020.
  4. Tsim KW, Dong TT, Wong ZC and Chan GK (2020).Preparation and applications of different ration of Cordyceps sinensis and Cordyceps militaris. China Patent CN 201510299155.4 filed on 3rd June, 2015 and issued on 15th May, 2020.
  5. Tsim KW, Wu KQ, Chan GK, Dong TT, Bai, BP (2019). A whitening agent and its application as cosmetics and pharmacological products. China Patent CN 201910756682.1, filed on 16th August, 2019.
  6. Cheung WT, Wan CR, Tsim KW, Chan GK, Cheung WH (2019). An extract of western green fruit and its antibacterial application. China Patent CN 201910282146.2, filed on 9th April, 2019.
  7. Tsim KW, Dong TT, Chan GK, Wong ZC, Wu KQ and Gridneva E (2019). New application of natural plant molecules of Chinese medicine. Hong Kong standard Patent 19120225.8, filed on 28th February, 2019.
  8. Lai YK, Chan GK, Huang M, Yang, HY, Cheng YT (2019). Modified herbal chips. China Patent ZL 201820814525.2, filed on 29th May, 2018 and issued on 19th February, 2019.
  9. Tsim KW, Dong TT, Chan GK, Duan, R (2018). Preparation and application of long-stem grape fern extract. China Patent CN 201811525384.3, filed on 13th December, 2018.
  10. Cheung FY, Cheung WT, Tsim KW, Dong TT, Chan GK, .Wong ZC, Wu KQ and Tam TT (2018). Composition Comprising Extract of Snowy Lotus and Bird’s Nest and Its Manufacture and Use. Hong Kong Standard Patent 18107455.3, filed on 7th June, 2018.
  11. Tsim KW, Chan GK, Cheng YT (2018). Preparation for accelerating wound healing, and preparation method and application thereof. China Patent ZL 201510135929.X, filed on 26th March, 2015 and issued on 1st June, 2018.
  12. Tsim KW, Chan GK, Cheng YT (2018). Species reduce skin inflammation formulation, preparation method and application. China Patent ZL 201510135928.5, filed on 26th March, 2015 and issued on 29th May, 2018.
  13. Tsim KW, Chan GK, Cheng YT (2018). Preparation for depression relief, preparation method and application thereof. China Patent ZL 201510136095.8, filed on 26th March, 2015 and issued on 16th January, 2018.
  14. Tsim KW, Dong TT and Chan GK (2018). Method for inhibiting production of nitrite in edible bird’s nest. Hong Kong standard Patent 1197162, filed on 29th October, 2014 and issued on 12th January, 2018.
  15. Tsim KW, Chan GK, Dong TT, Fung AH, Poon KK (2018). A method of releasing growth factors for the application in skin regeneration and whitening products. China Patent ZL 201810029948.8, filed on 12th January, 2018.
  16. Tsim KW, Dong TT, Chan GK, Wong ZC, Wu KQ and Gridneva E (2017). The application of Chinese medicine derived herbal compounds on skin tanning. China Patent ZL 201710338669.5, filed on 12th May, 2017.
  17. Tsim KW, Dong TT, Chan GK, Lee YK, Xu JT and Ho CM (2017). A natural molecular formulation with skin whitening effect and its application. China Patent ZL 201710307952.1, filed on 4th May, 2017.
  18. Tsim KW, Dong TT, Wong ZC, Chan GK and Tam TT (2017). New preparation method of cubilose extract and its application. China Patent ZL 201710197243.2, filed on 29th March, 2017.
  19. Tsim KW, Dong TT, Chan GK, Wong ZC and Wu KQ (2017). Preparation method and application of aqueous extract of Gentiana flowers. China Patent ZL 201710143037.3, filed on 10th March, 2017.
  20. Tsim KW, Dong TT, Chan GK and Wang B (2017). Extraction of Cordyceps militaris and its applications. China Patent ZL 201410093018.2, filed on 13th March, 2014 and .issued on 18th January, 2017.
  21. Tsim KW, Dong TT and Chan GK. (2016). A method of inhibiting the production of nitrite in edible bird’s nest. China Patent ZL 201210464527.0, filed on 16th November, 2012 and issued on 21st November, 2016.
  22. Cheung FY, Cheung WT, Tsim KW, Dong TT, Chan GK, .Wong ZC, Wu KQ and Tam TT (2016). Composition Comprising Extract of Snowy Lotus and Bird’s Nest and Its Manufacture and Use. China Patent ZL 201610980454.9, filed on 8th November, 2016.
  23. Tsim KW, Dong TT and Chan GK. (2015). A Preparation Method of Edible Bird's Nest Extract with Inhibitory Effect on Tyrosinase and Potency of Skin Whitening. China Patent ZL 2013 1 0391376.5, filed on 30th August, 2013 and issued on 14th October, 2015.
  24. Chan GK, Tsim KW, Wan DC, Cheung FY and Wen C (2015). A preparation method of edible bird’s nest extract with strong antioxidant capacity. Hong Kong Standard Patent 1187076, filed on 6th January, 2014 and issued on 11th September, 2015.
  25. Chan GK, Tsim KW, Wan DC, Cheung FY and Wen C (2015). A preparation method of edible bird’s nest extract with strong antioxidant capacity. China Patent ZL 2013 1 0331828.0, filed on 2nd August, 2013 and issued on 25th March, 2015.
  26. Cheung FY, Wen C, Tsim KW, Dong TT, Wang B and Chan GK (2015). Extract of Cordyceps, preparation method and use thereof. Hong Kong Short-Term Patent 1197713, filed on 10th November, 2014 and issued on 6th February, 2015.
  27. Chan GK, Tsim KW, Wan DC, Cheung FY and Wen C (2013). A preparation method of edible bird’s nest extract with strong antioxidant capacity. Hong Kong Short-Term Patent 1182888, filed on 1st August, 2013 and issued on 6th December, 2013.
  28. Tsim KW, Dong TT, Chan GK and Wang T. (2013). A method for determining free sialic acid content in cubilose to identify cubilose quality. Macau Patent J000949, issued on 25th February, 2013.
  29. Tsim KW, Dong TT, Chan GK and Wang T. (2012). A method for determining free sialic acid content in cubilose to identify cubilose quality. China Patent ZL 2010 1 0162516.8, filed on 9th April, 2010 and issued on 26th September, 2012.
  30. Tsim KW, Dong TT and Chan GK. (2011). A detection method for identification of the quality of edible bird’s nest. Hong Kong Short-Term Patent 1147388, filed on 8th April, 2011 and issued on 5th August, 2011.