How Crowns OFF® Effervescent Tablet Combats COVID-19?
The bioactive ingredients in Crowns OFF® fight COVID-19 in different pathways:
- By competing with the ACE2 receptor on cell membrane surfaces, Crowns OFF® Naringenin & Quercetin Effervescent Tablet reduces the BINDING CAPACITY between the virus-caused COVID-19 (i.e. SARS-CoV-2) and ACE2. Hence, it lowers the ability for SARS-CoV-2 to enter our cells (Pro-active Measure).
- Even when the virus successfully invades our cells, Crowns OFF® could attenuate 3CL protease activity to slow down the replication of SARS-CoV-2 (Re-active Measure).
- Some people in Hong Kong who have recovered from COVID-19 infection suffer from a kind of tissue damage due to “cytokine storm”. Crowns OFF® Effervescent Tablet comprises Naringenin and Quercetin, which helps attenuate inflammation induced by down-regulating pro-inflammatory markers via NF-kB signalling pathway (Post-active Measure).
In conclusion, Crowns OFF® Effervescent Tablet provides us with an ALL-ROUNDED PROTECTION against COVID-19
Activation of neuron after treatment of active ingredients in Crowns OFF®
Can Crowns OFF® Effervescent Tablet Beat LONG COVID?
One of the most severe syndromes in LONG COVID was the so-called “BRAIN FOG” or its original name, “clouding / disturbance of consciousness”. The description of pharmacology in Brain Fog was highly similar to the brain disorder (e.g. Depression) in Traditional Chinese Medicinal theory. One of the major components in Crowns OFF® Effervescent Tablet — Quercetin, could reactivate the brain cells and provide an effective remedy for brain fog.
What are the ingredients of Crowns OFF® Effervescent Tablet ? Are there harmful ingredients?
Crowns OFF® Effervescent Tablet is a natural herbal formulation without preservatives and artificial chemicals. It is beneficial to your health and helps boost your immune system. Besides, the tablet features potent ingredients such as naringin and quercetin, which provide strong anti-inflammatory, anti-virus, and antioxidant effects to protect your health in Hong Kong. Additionally, Crowns OFF® Effervescent Tablet boasts excellent properties for controlling your glucose level and targeting noticeable signs of ageing. It is the right fit for anyone looking for a health product in Hong Kong.
New formula with anti-influenza A ingredients added
Influenza A virus is a representative pathogen of the Orthomyxoviridae family, and due to its high antigenic variability and broad host range, it is an important pathogen causing seasonal influenza and pandemics.In view of this, the new version of Guanlefu has incorporated an anti-influenza A ingredient — sialic acid.
The surface of the influenza A virus is distributed with two key glycoprotein spikes—hemagglutinin (HA), which is responsible for recognizing and binding to sialic acid receptors on the surface of host cells, marking the first step in viral adsorption and the initiation of infection; and neuraminidase (NA), which, in the late stages of viral replication, is responsible for cleaving the sialic acid linkages between newly formed viral particles and host cells, facilitating viral release and spread. They are like the "key" and "door opener" for the virus to invade cells.
The starting point of influenza A infection:The primary step in influenza A virus infecting the human body is the specific binding of its HA protein to sialic acid receptors on the surface of epithelial cells in the human respiratory mucosa (primarily α-2,6-linked sialic acid, with α-2,3-linked sialic acid also present in the lower respiratory tract). Blocking this binding step can effectively prevent infection at its source.
Based on the infection mechanism of the influenza A virus, the role of sialic acid (primarily composed of N-acetylneuraminic acid, Neu5Ac) can be precisely identified as a "receptor mimic" or "molecular decoy."
Its core function is to preemptively occupy the receptor-binding site of the influenza A virus hemagglutinin (HA), preventing the virus from recognizing and binding to genuine host cells, thereby neutralizing its infectivity. This mechanism of action shares similarities with the strategy employed by influenza vaccines to induce antibodies for virus neutralization, but sialic acid directly provides a bindable "decoy target."
Mechanism of action
1. Direct binding of virus particles
Western Blot experiments confirm that the extract of edible bird's nest can directly bind to influenza A viruses (such as A/Aichi/2/68 (H3N2)).
2. Inhibit blood coagulation (block viral adsorption)
The Hemagglutination Inhibition (HAI) assay is a classic method for evaluating the ability of inhibitors to prevent viruses from adsorbing onto red blood cells. Studies have shown that trypsin-hydrolyzed bird's nest extract can effectively inhibit the hemagglutination of red blood cells by multiple influenza A virus strains, including human-derived H1N1/H3N2, avian-derived H5N3, and swine-derived H3N2, among others. This indicates that sialic acid occupies the binding sites of viral hemagglutinin, preventing it from recognizing sialic acid receptors on the cell surface.
3. Neutralization of virus infection (cell-level validation)
In the MDCK cell infection model, bird's nest extract can effectively neutralize the infectivity of influenza A virus and significantly reduce the cytopathic effect caused by the virus. Its inhibitory effect is dose-dependent and is effective against various influenza A viruses, including strains newly isolated in 2005, demonstrating its broad-spectrum and effective inhibitory action.
Advantages
Broad spectrum: Sialic acid exhibits inhibitory effects on various subtypes of influenza A viruses (such as H1N1, H3N2, H5N3, H3N8) originating from humans, birds, and pigs, without being restricted by the viral host source.
High safety: The high-concentration bird's nest extract used in the study did not produce toxicity to cells and red blood cells, which, combined with its long history of consumption as a traditional food, indicates its extremely high safety.
Natural source: Compared to synthetic drugs, sialic acid is derived from natural food sources, making it more acceptable as a dietary supplement or preventive measure.
Sialic acid (primarily Neu5Ac-based sialic acid glycoconjugates) acts as a highly efficient "receptor decoy" by mimicking host cell receptors, specifically binding to the hemagglutinin of influenza A virus and exerting a potent inhibitory effect during the initial stage of viral adsorption to cells. Its action is characterized by broad-spectrum efficacy, safety, and a well-defined mechanism.
Ingredients of Crowns OFF® Effervescent Tablet:
Acidity regulators, anticaking agents, emulsifiers, sweeteners, grapefruit extract, quercetin, naringin, naringenin, licorice extract, bird's nest extract.
What Are the Health Benefits of Naringin & Naringenin?
Primarily found in citrus fruits and tomatoes, naringin and naringenin are rich in antioxidant and anti-inflammatory properties, which help support your body’s response to oxidative stress and inflammation. They work with other potent ingredients in the Crowns OFF® Effervescent Tablet to prevent a variety of diseases such as diabetes and cardiovascular diseases.
Can Crowns OFF® Effervescent Tablet Boost My Immune System?
Yes. Our healthy drinks are rich in citrus extracts such as naringin and naringenin, which help boost your immunity and cardiovascular and bone health, supporting healthy metabolism as well as combating fatigue. Stay healthy and fight off infectious bacteria with Crowns OFF® Effervescent Tablet.
Direction for Use
Put 1-2 Crowns OFF® Effervescent Tablet in 100-200ml lukewarm or cold water. Enjoy a healthy and refreshing drink once the tablet has completely dissolved.
Crowns OFF® Effervescent Tablet Experiment
